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Objectives?Pulmonary tuberculosis (TB) is chronic communicable bacterial disease caused by Mycobacterium tuberculosis. The objective was to assess the performance in terms of knowledge and practice of pulmonary tuberculosis (PTB) program among directly observed treatment short course (DOTS) provider, lab technician, senior treatment supervisor (STS), senior tuberculosis laboratory supervisor (STLS), factors affecting knowledge and practice of PTB program, rate of detection, cure rate and to identify the gaps and underlying contributing factors in terms of supply, manpower, and infrastructure. Materials and Methods?A cross-sectional study was conducted on knowledge and practice of PTB program among DOTS Provider, lab technician, STS, STLS in ten designated tuberculosis center of West Tripura from May 2018 to April 2019. Simple random sampling method was followed for selecting DOTS provider and sample size of 50 was taken. Results?Majority (40.0%) of patients were in the age group of 31 to 40 years and mean age of 40.98?±?10.13 years. Females and males were 68.0 and 32.0%, respectively. Among DOTS provider, 66.0% had served for more than 5 years of service and 84.0% of them had verified address before starting the treatment. Conclusion?Majority of the DOTS provider had satisfactory knowledge and practice about PTB program. Proportion of the medical officers attending DOTS training was inadequate and there were adequate number of the health care workers who had attended DOTS training. There were no gaps found in proportion of the cases receiving the supervised treatment.
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ABSTRACT Rickettsial diseases (RD) are a group of endotheliotropic infectious diseases caused by different species of genera Rickettsia. RD are not an uncommon disease and may be misdiagnosed during the evaluation of acute febrile illness due to a lack of reliable serological marker and diagnostic culture methods. Clinical manifestation of RD varies from febrile illness with rashes and myalgia to fatal complications such as shock and respiratory failure. We describe a case of a young male who presented initially with acute febrile illness, followed by shock and respiratory failure, and unfortunately succumbed to death. A post-mortem examination showed histological features of endotheliotropic infection, such as interstitial / perivascular edema in various organs and noncardiogenic pulmonary edema (suggesting increased vascular permeability) and evidence of vasculitis in the lung, liver, and intestines. Molecular studies performed from lung, liver, and kidney tissue confirm the diagnosis of spotted fever group rickettsial disease due to Rickettsia conorii.
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Introduction: Turmeric also known as Curcuma longa thatis widely used as a spice, preservative, coloring agent, and asa household remedy is coming a long way as an alternativemanagement option for periodontal conditions. Curcumin themain yellow bioactive part of turmeric has huge spectrum ofactivity such as anti-inflammatory, antioxidant, antimutagenic,anticarcinogenic, anticoagulant, antidiabetic, antifertility,antibacterial, antiprotozoal, antiviral, antivenom, antiulcer,antifibrotic, hypotensive, and hypocholesteremic activities.The present study was conducted with the aim to determinethe effect of curcumin gel along with SRP in chronic gingivitiscases.Material and methods: The present prospective studyconsisted of 30 subjects as cases and controls respectively.The study was conducted in the department of periodontics ofthe hospital. Scaling was performed by piezoelectric scaler bytrained personnel. After, thorough clearance curcumin gel waslocally applied amongst the cases. All the patients were givensame postoperative instructions and medicaments. Followup was performed after 30 days and the values of gingivalindex were noted. All the data thus obtained was arranged ina tabulated form and analysed using SPSS software. Studentt test was used for statistical analysis and probability value ofless than 0.05 was regarded as significant.Results: The present study consisted of 30 patients as casesand 30 as controls. The mean age of the subjects was 36.42+/-5.22 years. The mean value at day 0 amongst the cases and thecontrols was 2.61+/-0.54 and 2.65+/-0.66 respectively. Themean value at day 30 amongst the cases and the controls was1.90+/-0.38 and 1.45+/-0.45 respectively. On applying studentt test there was a significant improvement amongst the casescompared to the controls on Day 30.Conclusion: Application of curcumin gel could also lead to adecrease in the chances of surgical treatment after SRP as thepocket depth improves significantly
ABSTRACT
Introduction: Turmeric also known as Curcuma longa thatis widely used as a spice, preservative, coloring agent, and asa household remedy is coming a long way as an alternativemanagement option for periodontal conditions. Curcumin themain yellow bioactive part of turmeric has huge spectrum ofactivity such as anti-inflammatory, antioxidant, antimutagenic,anticarcinogenic, anticoagulant, antidiabetic, antifertility,antibacterial, antiprotozoal, antiviral, antivenom, antiulcer,antifibrotic, hypotensive, and hypocholesteremic activities.The present study was conducted with the aim to determinethe effect of curcumin gel along with SRP in chronic gingivitiscases.Material and methods: The present prospective studyconsisted of 30 subjects as cases and controls respectively.The study was conducted in the department of periodontics ofthe hospital. Scaling was performed by piezoelectric scaler bytrained personnel. After, thorough clearance curcumin gel waslocally applied amongst the cases. All the patients were givensame postoperative instructions and medicaments. Followup was performed after 30 days and the values of gingivalindex were noted. All the data thus obtained was arranged ina tabulated form and analysed using SPSS software. Studentt test was used for statistical analysis and probability value ofless than 0.05 was regarded as significant.Results: The present study consisted of 30 patients as casesand 30 as controls. The mean age of the subjects was 36.42+/-5.22 years. The mean value at day 0 amongst the cases and thecontrols was 2.61+/-0.54 and 2.65+/-0.66 respectively. Themean value at day 30 amongst the cases and the controls was1.90+/-0.38 and 1.45+/-0.45 respectively. On applying studentt test there was a significant improvement amongst the casescompared to the controls on Day 30.Conclusion: Application of curcumin gel could also lead to adecrease in the chances of surgical treatment after SRP as thepocket depth improves significantly
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The aim of the study was to investigate probable carrier rate of the healthcare workers and screened for carriers of MRSA as they could pose a potential risk factor for nosocomial transmission when the same carrier are exposed to the hospital setting during their clinical postings. A total of 100 nasal swabs were collected from the nursing staff and doctors. Sterile cotton swabs moistened with glucose broth were used for sample collection. Swabs were cultured on to nutrient agar, blood agar, and mannitol salt agar, incubated at 35 °C for 48 hrs. Staphylococcus aureus was identified by standard methods according to CLSI guidelines. Methicillin resistance was detected by using cefoxitin disc 30pgm on Mueller Hinton agar with 4% NaCL Of the 100 samples screened 30(30%) strains of Staphylococcus aureus were isolated, out of which 16 (53.33%) were Methicillin resistant Staphylococcus aureus (MRSA) and 14 (46.66%) were methicillin sensitive Staphylococcus aureus (MSSA). The overall carriage rate of methicillin resistant Staphylococcus aureus in our study was 16% with the highest rate being seen among the nursing staff (19.35%) and clinical staff carriage rate was lesser (10.52%) as compared to the nursing staff. Chest department samples showed higher carriage rate (33.33%) followed by pediatrics department (28.57%). The present study revealed that HCWs who have contact with patients are at risk of acquisition and colonization with antimicrobial resistant bacteria especially MRSA. Transient hand colonization is the primary mean of cross transmission. Simply education of HCWs on hygienic measures especially proper hand wash is the key to overcome MRSA infection in ICUs.
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In India, as in other parts of the world, nonsyndromic cleft lip with or without cleft palate (NSCL±P) is a highly prevalent birth defect, its incidence in males being twice that in females. A case–control association study has been carried out with respect to homocysteine level and MTHFR C677T, A1298C and SLC19A1 (RFC1) G80A genotypes from an eastern Indian cohort to investigate whether Hcy and other Hcy-pathway genes also contribute to the risk level. While MTHFR 677T and SLC19A1 80G are individually and cumulatively risk factors, SLC19A1 80A appears to be protective against MTHFR 677T risk allele. Elevated Hcy associates with NSCL±P both in case mothers and cases. Significantly, this difference shows a gender bias: the level of elevation of Hcy in female cases is distinctly higher than in males, and more case females are hyperhomocyteinemic than the case males. It implies that compared with the males, higher level of Hcy is needed for NSCL±P to manifest in the females. We consider this as one of the possible factors why the incidence of this disorder in females is much lower than in males.